Congenital Lyme & co-infections

Instructor

John Lambert, MD
Full Clinical Professor at University College Dublin School of Medicine and Consultant in Infectious Diseases and Genitourinary Medicine at Mater Misericordiae University Hospital 

Description

This module provides an overview of perinatal risks and outcomes related to congenital Lyme and co-infections.

Learning objectives

1. Describe the differing perinatal outcomes in vertical transmission of Borreliosis.
2. List tick-borne pathogens that can be perinatally transmitted to a neonate.
3. Discuss risks to infant from perinatally-acquired Relapsing Fever Borrelia infection.

This session, Congenital Lyme & co-infections, is approved for 0.5 enduring AAFP Prescribed credits.

AAFP Prescribed credit is accepted by the American Medical Association as equivalent to AMA PRA Category 1 credit(s)™ toward the AMA Physician’s Recognition Award. When applying for the AMA PRA, Prescribed credit earned must be reported as Prescribed, not as Category 1.

The AAFP has reviewed One Health Medical Education for a Changing Climate and deemed it acceptable for AAFP credit. Term of approval is from 01/02/2024 to 01/01/2025. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

Evidence-based bibliography for further study

NICE Lyme disease: Diagnosis and management [M] person to person transmission; 2018; ISBN 9781473129191.

Lakos, A.; Solymosi, N. Maternal Lyme borreliosis and pregnancy outcome. Int. J. Infect. Dis. 2010, 14, e494-8.

MacDonald, A.B. Human fetal borreliosis, toxemia of pregnancy, and fetal death. Zentralbl. Bakteriol. Mikrobiol. Hyg. A. 1986, 263, 189–200.

MacDonald, A.B. Gestational Lyme Borreliosis. Rheum. Dis. Clin. North Am. 1989, 15, 657–677.

Maraspin, V.; Cimperman, J.; Lotrič-Furlan, S.; Pleterski-Rigler, D.; Strle, F. Treatment of erythema migrans in pregnancy. Clin. Infect. Dis. 1996, 22, 788–793.

Maraspin, V.; Cimperman, J.; Lotric Furlan, S.; Pleterski-Rigler, D.; Strle.F Erythema Migrans in Pregnancy. Wein Klin Wochenschr 1999, 10, 22–23.

Maraspin, V.; Ružić-Sabljić, E.; Pleterski-Rigler, D.; Strle, F. Pregnant women with erythema migrans and – -isolation of borreliae from blood: course and outcome after treatment with ceftriaxone. Diagn. Microbiol. Infect. Dis. 2011, 71, 446–8.

Markowitz, L.; Steere, A.; Benach, J.; Slade, J.; Broome CV Lyme Disease During Pregnancy. JAMA 1986, 255, 3394–6.

Nadal, D.; Hunziker, U.A.; Bucher, H.U.; Hitzig, W.H.; Duc, G. Infants born to mothers with antibodies against Borrelia burgdorferi at delivery. Eur. J. Pediatr. 1989, 148, 426–427.

Strobino, B.A.; Williams, C.L.; Abid, S.; Chalson, R.; Spierling, P. Lyme disease and pregnancy outcome: a prospective study of two thousand prenatal patients. Am. J. Obstet. Gynecol. 1993, 169, 367–74.

Strobino, B.; Abid, S.; Gewitz, M. Maternal Lyme disease and congenital heart disease: A case-control study in an endemic area. Am. J. Obstet. Gynecol. 1999, 180, 711–6.

Williams, C.L.; Strobino, B.; Weinstein, A.; Spierling, P.; Medici, F. Maternal Lyme disease and congenital malformations: a cord blood serosurvey in endemic and control areas. Paediatr. Perinat. Epidemiol. 1995, 9, 320–330.

MacDonald, A.B.; Benach, J.L.; Burgdorfer, W. Stillbirth following maternal Lyme disease. N. Y. State J. Med. 1987, 87, 615–6.

Gerber, M.A.; Zalneraitis, E.L. Childhood neurologic disorders and Lyme disease during pregnancy. Pediatr. Neurol. 1994, 11, 41–43.

Lavoie, P.; Duray, P.; et al Culture positive, seronegative, transplacental Lyme borreliosis infant mortality. Arthritis Rheum 1987, 3.

Walsh, C.A.; Mayer, E.W.; Baxi, L. V. Lyme disease in pregnancy: Case report and review of the literature. Obstet. Gynecol. Surv. 2007, 62, 41–50.

Schaumann, R.; Fingerle, V.; Buchholz, K.; Spencker, F.B.; Rodloff, A.C. Facial Palsy Caused by Borrelia Infection in a Twin Pregnancy in an Area of Nonendemicity. Clin. Infect. Dis. 1999, 29, 955–956.

Weber, K.; Bratzke, H.J.; Neubert, U.; Wilske, B.; Duray, P.H. Borrelia burgdorferi in a newborn despite oral penicillin for Lyme borreliosis during pregnancy. Pediatr. Infect. Dis. J. 1988, 7, 286–9.